The ALDH gene has two primary alleles. The dominant D allele results in production of
nonfunctional ALDH enzyme. This results in a build-up of acetaldehyde and a flush reaction
when an individual consumes alcohol. The recessive d allele results in production of a functional
ALDH enzyme and lack of a flush reaction. First, we are interested in the presence or absence of
the flush reaction phenotype.
1. Jasmine and her mother both get a flush reaction when they drink alcohol. Jasmine’s father
does not. Jasmine’s husband, Jake, does not get a flush reaction, but his mother and father
a. Draw a pedigree of Jasmine, Jake, and their parents. Label each individual with
b. What genotypic ratio is expected among Jasmine and Jake’s kids? Show your work
with a Punnett square.
c. What proportion of Jasmine and Jake’s kids are expected to exhibit the flush